The severity of hemolytic anemia varies among individuals with g6pd deficiency, making diagnosis more challenging in some cases. Glucose6phosphate dehydrogenase deficiency department of. C 3 neonates should be screened for g6pd deficiency when family history, ethnic or geographic origin, or the timing of the appearance of neonatal jaundice suggests the possibility of g6pd deficiency. The list of drugs and chemicals that need to be avoided is long, so. Avoid eating fava or broad beans and their products. Glucose6phosphate dehydrogenase g6pd deficiency is the most prevalent enzymopathy in mankind. G6pd deficiency is a genetic condition which affects the. Which medications should be avoided in patients with g6pd. If theres a g6pd deficiency diet, it may be a diet rich in antioxidants and healthy fats. Drugs causing haemolysis in g6pd deficiency subjects cuhk. Some drugs should be avoided by all g6pddeficient patients table 1. Glucose6phosphate dehydrogenase deficiency, the most common enzyme deficiency worldwide, causes a spectrum of disease including neonatal hyperbilirubinemia, acute hemolysis, and chronic hemolysis.
It is highly common in certain ethnic groups such as. As well as foods to avoid, there are many medications and household common chemicals that need to be avoided, like mothballs naphthalene, hair dyes, henna tattoos, menthol containing cleaners, rubs and also pesticides. Glucose6phosphate dehydrogenase deficiency orphanet. This is not a complete list of items that people with g6pd deficiency should avoid.
Always talk with your doctor before giving your child any medication. Pdf glucose6phosphate dehydrogenase g6pd deficiency. There are other medications that only cause red cell breakdown if taken in high doses. If you have g6pd deficiency, it doesnt mean you cannot take medications. Search drug groups, ingredients and trade names access limited to medical personnel and paying members drug names in red are of high risk to all deficiency variants. The following is a partial list of medications and chemicals that individuals with glucose6phosphate dehydrogenase g6pd deficiency should avoid. Glucose 6phosphate dehydrogenase g6pd deficiency is a genetic blood disorder where an acute attack of a haemolytic anaemia occurs.
Diagnosis and management of g6pd deficiency american. Symptoms can be triggered by the use of certain drugs. Acute hemolytic anemia from eating fava beans favism can be rapid. You should be aware of common medications to avoid. A child may have a slightly elevated temperature within 2448 hours and can become irritable and unruly, or subdued and lethargic. Favism can occur at any age, but occurs more often and more severely in children. Identification of g6pd deficiency and patient education regarding safe and unsafe medications and foods is critical to preventing future episodes of hemolysis. Anaesthetic management should focus on avoiding drugs that cause oxidative stress. G6pd deficiency foods to avoid list nutrition adventures. In addition, table 2 presents a partial list of reasonably safe medications for g6pd. Asians, africans and mediterranean and more prevalent in males more than females 1,2. People with g6pd deficiency can generally enjoy normal health.
918 1088 1131 13 1147 360 11 905 791 1592 1249 1360 169 71 174 684 1120 917 48 1530 692 592 682 693 461 322 1214 1377 168 419 344 1481 822 354